How has disease impacted the evolution of Japan’s culture and society? Sakai Shizu, a leading researcher in Japanese medical history, chronicles the litany of illnesses that have plagued Japan over time, unearthing recorded incidents and literary anecdotes in a vivid exploration of its history and society. Tales of Plague and Pestilence delves into how afflictions from vengeful spirits and malign deities to smallpox, cholera, and influenza as well as syphilis, cancer, and diabetes have caused suffering and the varied efforts, whether informed by faith or medicine, to stave off and cure them. In doing so, it presents a compelling cultural history, shedding light on the pivotal role of disease and epidemic in shaping the political and societal dynamics of Japan past and present.